Hongxia Ren
Neuroscience · Indiana University
Publications
57
Citations
1,690
Est. group size
—
Recurring co-author estimate
Active years
23
Publishing since 2004
Hongxia Ren studies how the body regulates appetite, blood sugar, and body weight, with a focus on signaling molecules called G protein-coupled receptors (particularly GPR17) that influence hormones like leptin and insulin. Much of the work uses mouse models and human genetic variants to understand and potentially treat obesity and type 2 diabetes. The research spans basic biology of metabolism through the discovery of drug-like compounds aimed at these receptors.
Publication activity has been variable year to year but remains active, with a notable increase in output in 2025.
Generated by claude-opus-4-8 from public bibliographic data · Jul 11, 2026
- G Protein‐Coupled Receptor 17 (Gpr17) Enhances Leptin and Insulin Sensitivity in Lean and Obese Mouse Models
Obesity · 2026
- Discovery of novel and selective GPR17 antagonists as pharmacological tools for developing new therapeutic strategies in diabetes and obesity
European Journal of Medicinal Chemistry · 2025
- Laparoscopic management of congenital gastric muscular layer defect and gastric perforation: a case series
World Journal of Pediatric Surgery · 2025
- Impact of Empagliflozin on Cardiovascular Outcomes and Renal Function in Patients with Obesity and Type 2 Diabetes: A Retrospective Cohort Study
Diabetes Therapy · 2025
- 2149-LB: G Protein-Coupled Receptor 17 (GPR17) Enhances Leptin and Insulin Sensitivity in Lean and Obese Mouse Models
Diabetes · 2025
- 2181-LB: Tirzepatide Synergizes with Leptin on Weight Loss and Restoring Metabolic Homeostasis Responsiveness in Diet-Induced Obesity Model
Diabetes · 2025
- The value of MMP-7 combined with serological markers in diagnosing liver fibrosis in children with biliary atresia
BMC Pediatrics · 2025
- Tirzepatide Synergizes with Leptin on Weight Loss and Restoring Metabolic Homeostasis in Diet-induced Obesity Model
bioRxiv (Cold Spring Harbor Laboratory) · 2025
- Discovery of Novel and Selective GPR17 Antagonists as Pharmacological Tools for Developing New Therapeutic Strategies in Diabetes and Obesity
bioRxiv (Cold Spring Harbor Laboratory) · 2024
- G Protein-Coupled Receptor 17 Inhibits Glucagon-like Peptide-1 Secretion via a Gi/o-Dependent Mechanism in Enteroendocrine Cells
Biomolecules · 2024
- G protein-coupled receptor 17 inhibits glucagon-like peptide-1 secretion via a Gi/o-dependent mechanism in enteroendocrine cells
bioRxiv (Cold Spring Harbor Laboratory) · 2024
- 1356-P: Investigating the Metabolic Function of an Orphan G Protein–Coupled Receptor in the Intestinal Epithelium
Diabetes · 2022
- Decision letter: Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
2022
- A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues
Journal of Biological Chemistry · 2021
- Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles
Journal of Biological Chemistry · 2021
- Diabetes×5
- Journal of Biological Chemistry×3
- bioRxiv (Cold Spring Harbor Laboratory)×3
- Journal of the Endocrine Society×3
- BMC Medical Genomics×2
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 11, 2026.
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