LabCompass

Herman O. Sintim

Immunology and Microbiology · Purdue University West Lafayette

OpenAlex ORCID
Mid career · publishing since 2004Rising activity
interferon and immune responsesBacterial biofilms and quorum sensingAdvanced biosensing and bioanalysis techniquesBacterial Genetics and BiotechnologyDNA and Nucleic Acid Chemistry

Publications

265

Citations

7,841

Est. group size

~19

Recurring co-author estimate

Active years

23

Publishing since 2004

Research summary
AI-generated

Herman O. Sintim's research focuses on the chemistry and biology of cyclic dinucleotides and related signaling molecules, including their role in bacterial and immune signaling pathways such as cGAS-STING. His group also develops small-molecule inhibitors targeting enzymes involved in cancer (such as RET and kinase pathways), bacterial resistance, and inflammation, working at the interface of chemical biology, medicinal chemistry, and microbiology.

Cyclic dinucleotide signaling (c-di-AMP, cGAMP) and STING pathway agonists/antagonistsKinase inhibitor design for cancer therapy (RET, FLT3, TAK1, MNK)Bacterial biofilm, quorum sensing, and antimicrobial resistanceNucleic acid and phosphodiesterase chemistry (including PDE-stable analogs)Biosensors and small-molecule probes for tracking cellular signaling

Publication output has fluctuated over the last decade with a notable spike in 2023, followed by a return to a steady average of roughly 16 papers per year in recent years.

Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026

Publication cadence
Publications per year over the last 10 years — averaging 15.8/year recently
2017: 12 publications172018: 22 publications182019: 13 publications192020: 18 publications202021: 9 publications212022: 8 publications222023: 46 publications46232024: 12 publications242025: 11 publications252026: 2 publications26
Recent publications
Publishes in
  • RSC Medicinal Chemistry×7
  • European Journal of Medicinal Chemistry×6
  • Chemical Communications×5
  • Journal of Medicinal Chemistry×5
  • Future Medicinal Chemistry×4
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This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.

Last updated Jul 20, 2026.

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