Helen Chamberlin
Biochemistry, Genetics and Molecular Biology · The Ohio State University
Publications
135
Citations
1,506
Est. group size
~2
Recurring co-author estimate
Active years
40
Publishing since 1987
Helen Chamberlin studies the genetics and evolution of developmental signaling pathways using the roundworm Caenorhabditis elegans and related nematode species as model organisms. Her work examines how genes controlling processes like vulval development, cell signaling (Notch and Ras pathways), and gene duplication change and adapt across related worm species, and includes efforts to build reference genome assemblies and computational modeling tools for studying gene networks. Students in this area would work with genetic model organisms to understand how developmental gene functions evolve over time.
Publication output was relatively steady through the late 2010s and early 2020s (peaking around 2019) but has declined noticeably in the last few years, dropping to just 1-3 papers annually since 2023.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- A gap-free, telomere-to-telomere genome assembly for the <i>Caenorhabditis briggsae</i> reference strain AF16
G3 Genes Genomes Genetics · 2026
- Coincident evolution and functional adaptation of the taxonomically restricted genes <i>ivph-3</i> and <i>gon-14</i> in <i>Caenorhabditis</i> nematodes
Biology Open · 2025
- Gene duplication and evolutionary plasticity of <i>lin-12/Notch</i> gene function in <i>Caenorhabditis</i>
Genetics · 2024
- Functional distinction in oncogenic Ras variant activity in <i>Caenorhabditis elegans</i>
Disease Models & Mechanisms · 2024
- Genetic characterization of <i>C. elegans</i><scp><i>TMED</i></scp> genes
Developmental Dynamics · 2023
- Efficient parameter generation for constrained models using MCMC
Scientific Reports · 2023
- Efficient identification of parameter space structure with Modified Metropolis-Hastings algorithm
Research Square · 2023
- Discovery of nonautonomous modulators of activated Ras
G3 Genes Genomes Genetics · 2022
- Faculty Opinions recommendation of Mechanism of life-long maintenance of neuron identity despite molecular fluctuations.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2022
- Faculty Opinions recommendation of Evolutionary plasticity in the requirement for force exerted by ligand endocytosis to activate C. elegans Notch proteins.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2022
- Faculty Opinions recommendation of Feedforward regulatory logic controls the specification-to-differentiation transition and terminal cell fate during Caenorhabditis elegans endoderm development.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2022
- A novel parameter sampling method efficiently uncovers unique properties for sets of mathematical models
Research Square · 2022
- Faculty Opinions recommendation of Mode and tempo of 3D genome evolution in Drosophila.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2022
- Coordination of local and long range signaling modulates developmental patterning
Journal of Theoretical Biology · 2021
- Faculty Opinions recommendation of An essential role for the piRNA pathway in regulating the ribosomal RNA pool in C. elegans.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2021
- Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature×23
- G3 Genes Genomes Genetics×2
- Cancer Research×2
- Research Square×2
- Developmental Cell×1
- Hongfei Ji
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Hannah L. Hertz
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Christopher Fang‐Yen
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Samuel Ward
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Daniella E. Chusyd
Biochemistry, Genetics and Molecular Biology · Indiana University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 19, 2026.
Claim or correct this profile