Brian P. H. Metzger
Biochemistry, Genetics and Molecular Biology · Purdue University West Lafayette
Publications
33
Citations
1,266
Est. group size
—
Recurring co-author estimate
Active years
17
Publishing since 2008
Brian P. H. Metzger studies how genes and proteins change over evolutionary time, combining laboratory experiments in yeast with computational analysis of protein sequences. His work examines how mutations in DNA regulatory regions and protein-coding sequences affect gene expression, protein structure, and evolutionary outcomes, including how randomness and historical contingency shape which evolutionary paths are possible. This research helps explain the predictability (or unpredictability) of evolution at the molecular level.
Publication output has fluctuated over the last decade with no clear steady growth, showing peaks in 2021 and 2024 interspersed with quieter years, and a modest 5-year average of under 2 papers per year.
Generated by claude-sonnet-5 from public bibliographic data · Jul 20, 2026
- The simplicity of protein sequence-function relationships
Nature Communications · 2024
- Epistasis facilitates functional evolution in an ancient transcription factor
eLife · 2024
- Frequent transitions in self-assembly across the evolution of a central metabolic enzyme
Nature Communications · 2024
- Genetic code robustness and protein evolvability are correlated and protein-specific
PLoS Biology · 2024
- On the Analysis of Protein Genetic Architecture: Response to “Protein sequence landscapes are not so simple”
bioRxiv (Cold Spring Harbor Laboratory) · 2024
- Author response: Epistasis facilitates functional evolution in an ancient transcription factor
2024
- Epistasis facilitates functional evolution in an ancient transcription factor
eLife · 2023
- The simplicity of protein sequence-function relationships
bioRxiv (Cold Spring Harbor Laboratory) · 2023
- Epistatic drift causes gradual decay of predictability in protein evolution
Science · 2022
- Contingency and chance erase necessity in the experimental evolution of ancestral proteins
eLife · 2021
- Mutational sources of trans-regulatory variation affecting gene expression in Saccharomyces cerevisiae
eLife · 2021
- Contingency and chance erase necessity in the experimental evolution of ancestral proteins
Open MIND · 2021
- Mutational sources of <i>trans-</i> regulatory variation affecting gene expression in <i>Saccharomyces cerevisiae</i>
bioRxiv (Cold Spring Harbor Laboratory) · 2021
- Author response: Contingency and chance erase necessity in the experimental evolution of ancestral proteins
2021
- Author response: Mutational sources of trans-regulatory variation affecting gene expression in Saccharomyces cerevisiae
2021
- bioRxiv (Cold Spring Harbor Laboratory)×7
- eLife×5
- Molecular Biology and Evolution×2
- Nature Communications×2
- Nature×1
- Vitor Antonio Corrêa Pavinato
Biochemistry, Genetics and Molecular Biology · The Ohio State University
- Gregory J. Velicer
Biochemistry, Genetics and Molecular Biology · Indiana University
- Craig E. Jackson
Biochemistry, Genetics and Molecular Biology · Indiana University
- Canan Karakoç
Biochemistry, Genetics and Molecular Biology · Indiana University
- Abhishek Mishra
Biochemistry, Genetics and Molecular Biology · The Ohio State University
This profile was generated automatically from public scholarly data (OpenAlex). Group size and activity levels are estimates derived from co-authorship patterns.
Last updated Jul 20, 2026.
Claim or correct this profile